Kristy A Brown Selected Research

Aromatase (CYP19)

1/2021	Targeting obesity-related dysfunction in hormonally driven cancers.
1/2020	Withdrawal: Hsp90 and PKM2 drive the expression of aromatase in Li-Fraumeni syndrome breast adipose stromal cells.
1/2019	Estrogens and breast cancer: Mechanisms involved in obesity-related development, growth and progression.
1/2018	IL-10 suppresses TNF-α-induced expression of human aromatase gene in mammary adipose tissue.
1/2018	Obesity and breast cancer - Role of estrogens and the molecular underpinnings of aromatase regulation in breast adipose tissue.
4/2017	Metabolic Obesity, Adipose Inflammation and Elevated Breast Aromatase in Women with Normal Body Mass Index.
1/2017	Menopause Is a Determinant of Breast Aromatase Expression and Its Associations With BMI, Inflammation, and Systemic Markers.
1/2017	Des-acyl ghrelin inhibits the capacity of macrophages to stimulate the expression of aromatase in breast adipose stromal cells.
12/2016	Inflammation, dysregulated metabolism and aromatase in obesity and breast cancer.
1/2016	Hsp90 and PKM2 Drive the Expression of Aromatase in Li-Fraumeni Syndrome Breast Adipose Stromal Cells.

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Kristy A Brown Research Topics

Disease

36	Breast Neoplasms (Breast Cancer) 01/2022 - 12/2008
23	Obesity 01/2021 - 07/2009
21	Neoplasms (Cancer) 01/2021 - 05/2011
14	Inflammation (Inflammations) 01/2022 - 03/2005
3	Insulin Resistance 11/2021 - 01/2017
2	Triple Negative Breast Neoplasms 10/2020 - 01/2017
2	Neoplasm Metastasis (Metastasis) 10/2020 - 01/2020
2	Li-Fraumeni Syndrome 01/2020 - 01/2016
1	Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome) 11/2021
1	COVID-19 11/2021
1	Hyperglycemia 11/2021
1	Carcinogenesis 01/2019
1	Hypertrophy 04/2017
1	Carcinoma (Carcinomatosis) 01/2017
1	Ductal Carcinoma 06/2014
1	Noninfiltrating Intraductal Carcinoma (DCIS) 06/2014
1	Gynecomastia 12/2013
1	Peutz-Jeghers Syndrome (Polyposis, Hamartomatous Intestinal) 12/2013
1	Hypoxia (Hypoxemia) 04/2013
1	Type 2 Diabetes Mellitus (MODY) 01/2012
1	Necrosis 07/2011

Drug/Important Bio-Agent (IBA)

29	Estrogens (Estrogen)FDA Link 01/2022 - 12/2008
25	Aromatase (CYP19)IBA 01/2021 - 07/2009
10	Hormones (Hormone)IBA 11/2021 - 07/2011
9	EnzymesIBA 01/2019 - 06/2014
7	Estrogen ReceptorsIBA 01/2020 - 05/2011
5	Insulin (Novolin)FDA Link 01/2022 - 01/2012
5	AdipokinesIBA 01/2021 - 01/2010
4	AndrogensIBA 01/2022 - 08/2014
4	GhrelinIBA 01/2020 - 08/2014
4	Dinoprostone (PGE2)FDA Link 12/2015 - 04/2013
3	Gonadal Steroid Hormones (Sex Hormones)IBA 01/2022 - 01/2022
3	LeptinIBA 01/2021 - 01/2017
3	Metformin (Glucophage)FDA LinkGeneric 11/2018 - 07/2011
3	LipidsIBA 01/2018 - 12/2016
2	SteroidsIBA 01/2020 - 02/2013
2	C-Reactive ProteinIBA 04/2017 - 01/2017
2	Glucose (Dextrose)FDA LinkGeneric 01/2017 - 08/2015
2	des-n-octanoyl ghrelinIBA 01/2017 - 01/2016
2	CytokinesIBA 08/2015 - 01/2012
1	Progesterone FDA LinkGeneric 01/2022
1	Biological ProductsIBA 01/2022
1	Sex Hormone-Binding GlobulinIBA 01/2022
1	AdiponectinIBA 11/2021
1	GlucocorticoidsIBA 11/2021
1	TESIBA 01/2020
1	Immunoglobulins (Immunoglobulin)IBA 01/2020
1	Proteins (Proteins, Gene)FDA Link 01/2020
1	Growth Hormone (Somatotropin)IBA 01/2020
1	Biomarkers (Surrogate Marker)IBA 01/2020
1	Tamoxifen FDA LinkGeneric 11/2018
1	4,4- difluoro- 4- bora- 3a,4a- diaza- s- indacene (BODIPY)IBA 01/2018
1	Interleukin-10 (Interleukin 10)IBA 01/2018
1	Triglycerides (Triacylglycerol)IBA 04/2017
1	Estrogen Receptor betaIBA 01/2017
1	Interleukin-6 (Interleukin 6)IBA 01/2017
1	Estrogen Receptor alphaIBA 01/2017
1	AcidsIBA 01/2016
1	Peptide Hormones (Polypeptide Hormones)IBA 01/2016
1	Ghrelin ReceptorsIBA 01/2016
1	Facilitative Glucose Transport Proteins (Glucose Transporter)IBA 08/2015
1	Messenger RNA (mRNA)IBA 08/2015
1	VimentinIBA 06/2015
1	Androgen Receptors (Androgen Receptor)IBA 06/2014
1	Formaldehyde (Formol)FDA Link 06/2014
1	ParaffinIBA 06/2014
1	Small Interfering RNA (siRNA)IBA 05/2014
1	Protein Isoforms (Isoforms)IBA 05/2014
1	AMP-Activated Protein KinasesIBA 04/2013
1	Oxygen (Dioxygen)IBA 04/2013
1	ProstaglandinsIBA 01/2012
1	Insulin-Like Growth Factor I (IGF-1)IBA 01/2012
1	Estradiol (Delestrogen)FDA LinkGeneric 11/2011
1	ColforsinIBA 07/2011
1	Aromatase InhibitorsIBA 07/2011
1	Phorbol EstersIBA 07/2011
1	Dexamethasone (Maxidex)FDA LinkGeneric 07/2011
1	AMP-Activated Protein Kinase KinasesIBA 09/2010
1	ElementsIBA 07/2009
1	Cyclic AMP (AMP, Cyclic)IBA 07/2009
1	Carrier Proteins (Binding Protein)IBA 07/2009
1	P-SelectinIBA 03/2005

Therapy/Procedure

5	Therapeutics 10/2020 - 01/2012
3	Mastectomy (Mammectomy) 01/2018 - 01/2017
1	Length of Stay 11/2021
1	Bariatric Surgery 01/2021